Pediatric Brain Tumor Foundation
In 2019, TMF funded a nationwide clinical trial for a drug to treat pediatric low-grade gliomas, a type of brain tumor. The drug targets unresectable tumors that have several genetic mutations. Based on the overwhelmingly favorable preliminary results, many families are asking for their children to remain on the drug for longer than originally budgeted or funded in the trial.
Children’s Hospital at Columbia Medical University
From 2014 to present TMF has funded comprehensive genetic sequencing at Columbia University Medical Center that enables personalized treatments for individual patients, vital clinical grade sequencing, and therapeutic recommendations for high-risk pediatric cancer patients. Of the patients sequenced the past 18 months, 78% (up from 67%) had clinically impactful findings resulting in diagnostic confirmation and treatment protocols that would not otherwise have been identified. Columbia analyzes both the DNA and RNA of the tumor as well as its copy number variation (CNV). 58% of clinically impactful findings came from RNA sequencing and/or CNV analysis. These personalized treatments hold great promise for pediatric cancer patients.
Customized treatments targeting the precise characteristics of a child’s tumor is a groundbreaking change from the one-size fits all approach used to date.
What distinguishes Columbia as a leader in the field of personalized medicine are the breadth and depth of clinical expertise across disciplines, the rich and diverse patient population they attract, and access to world-renowned research faculty. At Columbia success is measured one patient/one family at a time.
From 2009-2010 tay-bandz funded a pre-clinical testing program used to establish cell lines from patients who have rare tumors and to then use them to test novel therapeutics.
From 2005-2009 tay-bandz supported several faucets of solid tumor research including research to understand the biology of pediatric solid tumors. The goals were to understand the angiogenesis of pediatric solid tumors, evaluate agents in preclinical models and develop clinical trials with antiangiogenic agents. Additionally, tay-bandz supported the Development Therapeutics Program.
Memorial Sloan Kettering
TMF funded a study at Memorial Sloan Kettering, in 2014, for the use of a novel antibody to treat Desmoplastic Small Round Cell Tumors – a rare childhood cancer of the abdomen with a very poor prognosis. The trial was successfully completed and the survival rate increased dramatically. In 2018 and 2019, TMF granted additional funds enabling oncologists at MSK to determine if cancer cells are still circulating within seven days of tumor removal and injection of the antibody. This test offers real time confirmation of cancer eradication and helps to assess the need for additional treatment.
The National Institute of Health
TMF has funded the completion of a clinical grade master cell bank to support development of a new immunotherapy based vaccine for patients with pediatric sarcomas.
MD Anderson Cancer Center
MD Anderson Cancer Center: tay-bandz has funded research focused on pediatric osteosarcoma, a soft tissue sarcoma that can occur in adolescents and young adults.
One day in the life of a childhood cancer patient can be an eternity
Our goal has been and always will be to help children with cancer by funding cutting edge research that can impact their lives now, not years and miles of bureaucratic red tape from now.
We will never stop pushing the boundaries of conventional therapies, dated public policy, and the logjams that keep good drugs in the lab and out of the clinic. All our children deserve a bright and healthy future.